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Electron-overloadedmitochondria produces significant amount of superoxide anions that lead into nitric oxidedecrease, DNA damage, increased formation of AGEP?s, increased expression of the receptorfor AGEP?S, overactivity of hexosamine pathway, activation of protein kinase C and evenactivation of polyol pathway. and the urine ismade hyperosmotic and the urine ismade hyperosmotic.
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